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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Raniolo, S., Croce, S., Thomsen, R. P., Okholm, A. H., Unida, V., Iacovelli, F., Manetto, A., Kjems, J., Desideri, A. & Biocca, S. (2019). Cellular uptake of covalent and non-covalent DNA nanostructures with different sizes and geometries. Nanoscale, 11(22), 10808-10818. https://doi.org/10.1039/c9nr02006c

Camilli, L., Yu, F., Cassidy, A., Hornekær, L. & Bøggild, P. (2019). Challenges for continuous graphene as a corrosion barrier. 2D materials, 6(2), Article 022002. https://doi.org/10.1088/2053-1583/ab04d4

Jorgensen, A. L., Duncan, D. A., Kastorp, C. F. P., Kyhl, L., Tang, Z., Bruix, A., Andersen, M., Hammer, B., Lee, T.-L., Hornekaer, L. & Balog, R. (2019). Chemically-resolved determination of hydrogenated graphene-substrate interaction. Physical Chemistry Chemical Physics, 21(25), 13462-13466. https://doi.org/10.1039/c9cp02059d

Xia, D., Liu, S., Song, J., Li, Q., Xue, Q., Liang, C. & Dong, M. (2019). Confined hetero double helix structure induced by graphene nanoribbon. 2D materials, 6(3), Article 034001. https://doi.org/10.1088/2053-1583/aaf3cc

Juhl, D. W., Risør, M. W., Scavenius, C., Rasmussen, C. B., Otzen, D., Nielsen, N. C. & Enghild, J. J. (2019). Conservation of the Amyloid Interactome Across Diverse Fibrillar Structures. Scientific Reports, 9(1), Article 3863. https://doi.org/10.1038/s41598-019-40483-z

Hirsch, C., Jahnel, B. & Cali, E. (2019). Continuum percolation for Cox point processes. Stochastic processes and their applications, 129(10), 3941-3966. https://doi.org/10.1016/j.spa.2018.11.002

Fang, X., Wang, Z., Jiang, Z., Wang, J. & Dong, M. (2019). Coral-like S-doped CoSe₂ with enriched 1T-phase as efficient electrocatalyst for hydrogen evolution reaction. Electrochimica Acta, 322, Article 134739. https://doi.org/10.1016/j.electacta.2019.134739

Bregnhøj, M., Blázquez-Castro, A., Westberg, M., Breitenbach, T. & Ogilby, P. R. (2019). Correction to "Direct 765 nm Optical Excitation of Molecular Oxygen in Solution and in Single Mammalian Cells". Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 123(49), 10569-10569. https://doi.org/10.1021/acs.jpcb.9b10906

Nielsen, K. H. (2019). Cyberspace. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2019). Data. Weekendavisen, Sektion 4 (Ideer), 10.

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Kalinka Hansen