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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

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De Putte, D. V., Meshaka, R., Trahin, B., Habart, E., Peeters, E., Berné, O., Alarcón, F., Canin, A., Chown, R., Schroetter, I., Sidhu, A., Boersma, C., Bron, E., Dartois, E., Goicoechea, J. R., Gordon, K. D., Onaka, T., Tielens, A. G. G. M., Verstraete, L. ... Zhen, J. (2024). PDRs4All VIII. Mid-infrared emission line inventory of the Orion Bar. Astronomy and Astrophysics, 687, Article A86. https://doi.org/10.1051/0004-6361/202449295

Eriksen, C. B. (2024). Peering Horizontally Through the Microscope: Stephen Gaukroger Explains the Middling World. In C. Wolfe & A. Waldow (Eds.), Science and the Shaping of Modernity: Essays in Honor of Stephen Gaukroger (pp. 113-121). Springer. https://doi.org/10.1007/978-3-031-76037-2_12

Hobolth, A., Rivas-González, I., Bladt, M. & Futschik, A. (2024). Phase-type distributions in mathematical population genetics: An emerging framework. Theoretical Population Biology, 157, 14-32. https://doi.org/10.1016/j.tpb.2024.03.001

Zhang, Y., Su, H., Wang, W., Dong, M. & Han, X. (2024). Phospholipid Epitaxial Assembly Behavior on a Hydrophobic Highly Ordered Pyrolytic Graphite Surface. Langmuir, 40(2), 1439-1446. https://doi.org/10.1021/acs.langmuir.3c03145

Teodori, L., Kroer, S., Omer, M., Andersen, V. L., Bech, P., Su, J., Bridoux, J., Nielsen, J. S., Bertelsen, M. B., Hernot, S., Gothelf, K. V. & Kjems, J. (2024). Plug-and-play nucleic acid-mediated multimerization of biparatopic nanobodies for molecular imaging. Molecular Therapy - Nucleic Acids, 35(3), Article 102305. https://doi.org/10.1016/j.omtn.2024.102305

Brodszkij, E., Ryberg, C., Lyons, J. A., Juhl, D. W., Nielsen, N. C., Sigalas, N. I., Lyulin, A. V., Pedersen, J. S. & Städler, B. (2024). Poly(Sitosterol)-Based Hydrophobic Blocks in Amphiphilic Block Copolymers for the Assembly of Hybrid Vesicles. Small, 20(40), Article 2401934. https://doi.org/10.1002/smll.202401934

Greussing, E., Guenther, L., Baram-Tsabari, A., Dabran-Zivan, S., Jonas, E., Klein-Avraham, I., Taddicken, M., Beets, B., Brossard, D., Chakraborty, A., Agergaard, T. E., Fage-Butler, A., Ju Huang, C., Nielsen, K. H., Kankaria, S., Lo, Y.-Y., Riedlinger, M. & Song, H. J. (2024). Predicting and describing the use of generative AI in science-related information search: Insights from a multinational survey. Abstract from Annual Conference of the “Science Communication” Division of the German Communication Association 2024, Zürich, Switzerland. https://www.ikmz.uzh.ch/dam/jcr:f29f21aa-1025-4b39-b848-4aefbd13a781/AI&SCICOMM24_Book%20of%20Abstracts.pdf

Nielsen, K. H. (2024). Problemet med Central Park. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2024). Professorens prutter. Weekendavisen, Sektion 4 (Ideer), 5.

Malle, M. G., Song, P., Löffler, P. M. G., Kalisi, N., Yan, Y., Valero, J., Vogel, S. & Kjems, J. (2024). Programmable RNA Loading of Extracellular Vesicles with Toehold-Release Purification. Journal of the American Chemical Society, 146(18), 12410-12422. https://doi.org/10.1021/JACS.3C13123

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