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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Zhao, J., Zhang, Y., Zhang, X., Li, C., Du, H., Sønderskov, S. M., Mu, W., Dong, M. & Han, X. (2022). Mimicking Cellular Metabolism in Artificial Cells: Universal Molecule Transport across the Membrane through Vesicle Fusion. Analytical Chemistry, 94(9), 3811-3818. https://doi.org/10.1021/acs.analchem.1c04696

Sønderby, T. V., Zou, Y., Wang, P., Wang, C. & Otzen, D. E. (2022). Molecular-level insights into the surface-induced assembly of Functional Bacterial Amyloid. Biophysical Journal, 121(18), 3422-3434. https://doi.org/10.1016/j.bpj.2022.08.013

Aagaard, J. B., Sivelle, C., Fischer, M., Byskov, K., Laursen, N. S., Pfützner, W., Jakob, T., Möbs, C., Miehe, M. & Spillner, E. (2022). Nanobody-based human antibody formats act as IgE surrogate in hymenoptera venom allergy. Allergy: European Journal of Allergy and Clinical Immunology, 77(9), 2859-2862. https://doi.org/10.1111/all.15391

Xu, M., Zhang, D., Wang, Y., Zhang, Y., Li, Q. & Dong, M. (2022). Nanoscale friction of strained molybdenum disulfide induced by nanoblisters. Applied Physics Letters, 120(15), Article 151601. https://doi.org/10.1063/5.0087756

Qian, X., Ramos-Docampo, M. A., Ade, C., Brodszkij, E., Westensee, I. N. & Städler, B. (2022). Nitric oxide producing artificial enzymes based on metalloporphyrins. Materials Today Chemistry, 23, Article 100743. https://doi.org/10.1016/j.mtchem.2021.100743

Liang, X., Wang, Y., Song, J., Xia, D., Li, Q. & Dong, M. (2022). Nontoxic silicene photothermal agents with high near-infrared absorption for disassembly of Alzheimer's amyloid‑β fibrils. Colloids and Surfaces B: Biointerfaces, 216, Article 112575. https://doi.org/10.1016/j.colsurfb.2022.112575

Nielsen, K. H. (2022). O for original. Weekendavisen, Sektion 4 (Ideer), 5.

Spanjers, J. M., Brodszkij, E., Gal, N., Skov Pedersen, J. & Städler, B. (2022). On the assembly of zwitterionic block copolymers with phospholipids. European Polymer Journal, 180, Article 111612. https://doi.org/10.1016/j.eurpolymj.2022.111612

Gille, S. & Hirsch, C. (2022). On the splitting principle for cohomological invariants of reflection groups. Transformation Groups, 27(4), 1261-1285. https://doi.org/10.1007/s00031-020-09637-6

Ahmed, I. A., Liu, J.-J., Gieniec, K. A., Bair-Marshall, C. J., Adewakun, A. B., Hetzler, B. E., Arp, C. J., Khatri, L., Vanwalleghem, G. C., Seidenberg, A. T., Cowin, P., Trauner, D., Chao, M. V., Davis, F. M., Tsien, R. W. & Froemke, R. C. (2022). Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery. https://doi.org/10.1101/2022.11.10.516001

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Revised 03.03.2026

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Kalinka Hansen