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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, K. H. (2019). Kampen om vores gener. Weekendavisen, Sektion 4 (Ideer), 12.

Nielsen, K. H. (2019). Kuznets-kurven. Weekendavisen, Sektion 4 (Ideer), 10.

Pellerin, A., Antler, G., Holm, S. A., Findlay, A. J., Crockford, P. W., Turchyn, A. V., Jørgensen, B. B. & Finster, K. (2019). Large sulfur isotope fractionation by bacterial sulfide oxidation. Science Advances, 5(7), Article eaaw1480. https://doi.org/10.1126/sciadv.aaw1480

Nielsen, K. H. (2019). Laser. Weekendavisen, Sektion 4 (Ideer), 10.

Thøgersen, J., Bak, E. N., Finster, K., Nørnberg, P., Jakobsen, H. J. & Knak Jensen, S. J. (2019). Light on windy nights on Mars: A study of saltation-mediated ionization of argon in a Mars-like atmosphere. Icarus, 332, 14-18. https://doi.org/10.1016/j.icarus.2019.06.025

Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, H., Nielsen, H. M., van Eden, W., Dong, M., Broere, F., Foged, C. & Zeng, X. (2019). Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model. European Journal of Pharmaceutics and Biopharmaceutics, 142, 38-48. https://doi.org/10.1016/j.ejpb.2019.06.009

Song, P., Yang, C., Thomsen, J. S., Dagnaes-Hansen, F., Jakobsen, M., Bruel, A., Deleuran, B. & Kjems, J. (2019). Lipidoid-siRNA Nanoparticle-Mediated IL-1 beta Gene Silencing for Systemic Arthritis Therapy in a Mouse Model. Molecular Therapy, 27(8), 1424-1435. https://doi.org/10.1016/j.ymthe.2019.05.002

Zhang, Z., Dong, MD., Yang, F. & Wang, Z. (2019). Liposome induced mechanical properties changes in cell membrane. In 2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) (pp. 202-205). Article 8947412 https://doi.org/10.1109/3M-NANO46308.2019.8947412

Erslev, T. (Ed.) & Eriksen, C. B. (2019). Livsvidenskabernes materialitet. Slagmark: tidsskrift for idéhistorie , 1-189.

Eriksen, C. B. & Erslev, T. (2019). Livsvidenskabernes materialitet: En introduktion. Slagmark: tidsskrift for idéhistorie , 78, 7-28.

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