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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Lynge, M. E., Ogaki, R., Laursen, A. O., Lovmand, J., Sutherland, D. S. & Stadler, B. (2011). Polydopamine/Liposome Coatings and Their Interaction with Myoblast Cells. A C S Applied Materials and Interfaces, 3(6), 2142-2147. https://doi.org/10.1021/am200358p

Lynge, M. E., Ogaki, R., Laursen, A. O., Lovmand, J., Sutherland, D. S. & Stadler, B. M. (2011). Polydopamine/Liposome Coatings and Their Interaction with Myoblast Cells. A C S Applied Materials and Interfaces, 3(6), 2142-2147. https://doi.org/10.1021/am200358p

Alves, M.-H., Jensen, B. E. B., Smith, A. A. A. & Zelikin, A. N. (2011). Poly(vinyl alcohol) physical hydrogels : New vista on a long serving biomaterial. Macromolecular Bioscience, 11, 1293-1313.

Jensen, B. E. B., Smith, A. A. A., Fejerskov, B., Postma, A., Senn, P., Reimhult, E., Pla-Roca, M., Isa, L., Sutherland, D. S., Stadler, B. & Zelikin, A. N. (2011). Poly(vinyl alcohol) Physical Hydrogels: Non-cryogenic Stabilization Allows Nano- and Micro-Scale Materials Design. Langmuir, 27(16), 10216–10223. https://doi.org/10.1021/la201595e

Nørnberg, P., Vendelboe, A. L., Gunnlaugsson, H. P., Merrison, J. P., Finster, K. & Jensen, S. K. (2011). Possible formation of hematite and maghemite from goethite/ferrihydrite under temperate conditions. Abstract from Euroclay 2011, Antalya, Turkey.

Le, D. Q. S., Andersen, M. Ø., Baatrup, A., Chen, M., Chen, M., Lysdahl, H., Besenbacher, F., Bünger, C. & Kjems, J. (2011). Process for Modifying the Surface Morphology of a Medical Device: PA 2011 70752.

Otzen, D. (2011). Protein-surfactant interactions a tale of many states. BBA General Subjects, 1814(5), 562-91. https://doi.org/10.1016/j.bbapap.2011.03.003

Braren, I., Greunke, K., Grunwald, T., Pilette, C., Mempel, M., Bredehorst, R., Ring, J., Spillner, E. & Ollert, M. (2011). Quantitation of serum IgE by using chimeras of human IgE receptor and avian immunoglobulin domains. Analytical Biochemistry, 412(2), 134-140. https://doi.org/10.1016/j.ab.2010.12.013

Barndorff-Nielsen, O. E. & Basse-O'Connor, A. (2011). Quasi Ornstein-Uhlenbeck processes. Bernoulli, 17(3), 916-941. https://doi.org/10.3150/10-BEJ311

Simonsen, M. & Pedersen, C. N. S. (2011). Rapid Computation of Distance Estimators from Nucleotide and Amino Acid Alignments. In Proceedings of the 26th Annual ACM Symposium on Applied Computing Association for Computing Machinery.

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Kalinka Hansen