Publications

Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

Sort by: Date | Author | Title

Kania, K., Colella, F., Riemen, A. H. K., Wang, H., Howard, K., Aigner, T., Dell’Accio, F., Capellini, T. D., Roelofs, A. J. & De Bari, C. (2020). Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis. Scientific Reports, 10(1), 157. Article 157. https://doi.org/10.1038/s41598-019-57011-8

Godskesen, L. E., Lassen, T. R., Jespersen, N. R., Siersbæk, M., Yan, Y., Nielsen, M. M., Tjønnfjord, S. K., Grøntved, L., Madsen, G., Kjems, J., Bøtker, H. E., Schmidt, M. R., Krag, A. & Kjeldsen, J. (2020). Remote ischemic conditioning in active ulcerative colitis: An explorative randomized clinical trial. Scientific Reports, 10(1), Article 9537. https://doi.org/10.1038/s41598-020-65692-9

Pedersen, S. L., Huynh, T. H., Pöschko, P., Fruergaard, A. S., Jarlstad Olesen, M. T., Chen, Y., Birkedal, H., Subbiahdoss, G., Reimhult, E., Thøgersen, J. & Zelikin, A. N. (2020). Remotely Triggered Liquefaction of Hydrogel Materials. ACS Nano, 14(7), 9145-9155. https://doi.org/10.1021/acsnano.0c04522

Bailey, M. H., Meyerson, W. U., Dursi, L. J., Wang, L. B., Dong, G., Liang, W. W., Weerasinghe, A., Li, S., Kelso, S., Akbani, R., Anur, P., Bailey, M. H., Buchanan, A., Chiotti, K., Covington, K., Creason, A., Ding, L., MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium (2020). Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11(1), Article 4748. https://doi.org/10.1038/s41467-020-18151-y

Wang, Z., Wu, H. H., Li, Q., Besenbacher, F., Li, Y., Zeng, X. C. & Dong, M. (2020). Reversing Interfacial Catalysis of Ambipolar WSe₂ Single Crystal. Advanced Science, 7(3), Article 1901382. https://doi.org/10.1002/advs.201901382

Schiølin, K. (2020). Revolutionary dreams: Future essentialism and the sociotechnical imaginary of the fourth industrial revolution in Denmark. Social Studies of Science, 50(4), 542-566. https://doi.org/10.1177/0306312719867768

Nielsen, K. H. (2020). Science communication from the perspective of STS. In A. Turanlı, A. U. Aydınoğlu & M. Şahinol (Eds.), Türkiye’de STS: bilim ve teknoloji Çalışmalarına giriş (pp. 37-47). İstanbul Teknik Üniversitesi. http://hdl.handle.net/11527/18483

Krainer, G., Hartmann, A., Bogatyr, V., Nielsen, J., Schlierf, M. & Otzen, D. E. (2020). SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence. Chemical Science, 11(34), 9141-9153. https://doi.org/10.1039/d0sc02100h

Li, C. H., Prokopec, S. D., Sun, R. X., Yousif, F., Schmitz, N., PCAWG Tumour Subtypes and Clinical Translation, Boutros, P. C. & PCAWG Consortium (2020). Sex differences in oncogenic mutational processes. Nature Communications, 11, Article 4330. https://doi.org/10.1038/s41467-020-17359-2

Chen, M. (2020). She’s injecting ‘solar cells’ into the body to regenerate brain cells. In J. Bruun (Ed.), Profile 2020 (pp. 70-73). Aarhus Universitet, Institut for Ingeniørvidenskab . https://www.e-pages.dk/aarhusuniversitet/2231/html5/

Displaying results 1081 to 1090 out of 3503

109