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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

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Kirkegaard, K., Yan, Y., Sørensen, B. S., Hardason, T., Hanson, C., Ingerslev, H. J., Knudsen, U. B., Kjems, J., Lundin, K. & Ahlström, A. (2020). Comprehensive analysis of soluble RNAs in human embryo culture media and blastocoel fluid. Journal of Assisted Reproduction and Genetics, 37(9), 2199–2209. https://doi.org/10.1007/s10815-020-01891-7

Jiang, H., Wang, Z., Dong, L. & Dong, M. (2020). Co(OH)₂/MXene composites for tunable pseudo-capacitance energy storage. Electrochimica Acta, 353, Article 136607. https://doi.org/10.1016/j.electacta.2020.136607

Chen, C., Zhu, X., Wen, X., Zhou, Y., Zhou, L., Tao, L., Li, Q., Du, S., Liu, T., Yan, D., Xie, C., Zou, Y., Wang, Y., Chen, R., Huo, J., Li, Y., Cheng, J., Su, H., Zhao, X. ... Wang, S. (2020). Coupling N-2 and CO2 in H2O to synthesize urea under ambient conditions. Nature Chemistry, 12(8), 717-724. https://doi.org/10.1038/s41557-020-0481-9

Wang, Z. & Dong, M. (2020). Cutting Edge Materials of Two-Dimensional Platinum Diselenide. In L. Singh & D. M. Mahapatra (Eds.), Adapting 2D Nanomaterials for Advanced Applications (pp. 317-345). ACS (American Chemical Society). https://doi.org/10.1021/bk-2020-1353.ch013

Hjerrild, P., Tørring, T. & Poulsen, T. B. (2020). Dehydration reactions in polyfunctional natural products. Natural Product Reports, 37(8), 1043-1064. https://doi.org/10.1039/d0np00009d

Hetland, P., Kasperowski, D. & Nielsen, K. H. (2020). Denmark, Norway, and Sweden: Share, make useful and critically discuss science communication. In T. Gascoigne, B. Schiele, J. Leach, M. Riedlinger, B. V. Lewenstein, L. Massarani & P. Broks (Eds.), Communicating science: a global perspective (pp. 253-278). ANU Press. https://doi.org/10.22459/CS.2020

Finster, K. (2020). Derfor kan bakterier fra chilensk bjergsø bruges som kig til livets børneværelse. Ingeniøren, Sektion 1, 14-15.

Adão, R., Cruz, P. F., Vaz, D. C., Fonseca, F., Pedersen, J. N., Ferreira-da-Silva, F., Brito, R. M. M., Ramos, C. H. I., Otzen, D., Keller, S. & Bastos, M. (2020). DIBMA nanodiscs keep α-synuclein folded. Biochimica et biophysica acta - Biomembranes, 1862(9), Article 183314. https://doi.org/10.1016/j.bbamem.2020.183314

Ma, R., Haastrup, M. J., Wang, Z., Liu, Y., Ye, H., Dong, M., Lauritsen, J. V. & Sutherland, D. S. (2020). Direct Integration of Few-Layer MoS₂ at Plasmonic Au Nanostructure by Substrate-Diffusion Delivered Mo. Advanced Materials Interfaces, 7(8), Article 1902093. https://doi.org/10.1002/admi.201902093

Jiang, A., Zhang, W., Wang, Z., Nidamanuri, N. P., Li, Q., Zeng, X. C. & Dong, M. (2020). Direct synthesis of bifunctional nanorods from a Co-adenine-MoO₃ hybrid for overall water splitting. Materials Chemistry Frontiers, 4(2), 546-554. https://doi.org/10.1039/c9qm00626e

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