Publications

Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

Sort by: Date | Author | Title

Wittenborn, T., Nygaard, J. V., Horsman, M. R., Vorup-Jensen, T., Kjems, J., Thim, T., Nielsen, T., Larsen, E. K. U. & Falk, E. (2009). A Novel in Vivo Angiogenesis Mouse Model. Arteriosclerosis, Thrombosis, and Vascular Biology, (7).

Mailund, T., Nielsen, J. & Pedersen, C. S. (2009). A Quadratic Time Algorithm for Computing the Quartet Distance between Two General Trees. In Proceedings of IJCBS 2009 (pp. 565-568). IEEE Computer Society Press. https://doi.org/10.1109/IJCBS.2009.42

Balog, R., Jørgensen, B., Wells, J., Lægsgaard, E., Hofmann, P., Besenbacher, F. & Hornekær, L. (2009). Atomic hydrogen adsorbate structures on graphene. Journal of the American Chemical Society, 131(25), 8744. https://doi.org/10.1021/ja902714h

Kristensen, T. G., Nielsen, J. & Pedersen, C. N. S. (2009). A tree based method for the rapid screening of chemical fingerprints. Lecture Notes in Computer Science, 5724, 194-205. https://doi.org/10.1007/978-3-642-04241-6_17

Liboriussen, P., Pedersen, B. P., Ifrim, G., Nissen, P. & Pedersen, C. S. (2009). Automatic classification of P-Type ATPases using SLR. Poster session presented at 17th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & 8th European Conference on Computational Biology (ECCB), Stockholm, Sweden.

Huynh, T. H. V., Mantel, M., Mikkelsen, K., Lindhardt, A. T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2009). A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis. Organic Letters, 11, 999-1002.

Ebbesen, M. (2009). Bioethics in theory and practice.

Yde, J. C., Finster, K., Hodson, A. J., Knudsen, N. T., Bárcena, T. G., Bartholomew, I., Lawson, E., Nienow, P. W., Tranter, M. & Wadham, J. L. (2009). Biogeochemical processes in Greenlandic glacial waters. Poster session presented at 19th International Symposium on Environmental Biogeochemistry, Hamburg, Germany.

Finster, K. & Yde, J. C. (2009). Biogeochemical studies of glacial ecosystems in Greenland. Poster session presented at Beyond Kyoto: Addressing the Challenges of Climate Change - Science meets Industry, Policy and the Public, Århus, Denmark.

Søbjerg, L. S., Gauthier, D., Lindhardt, A. T., Bunge, M., Finster, K., Meyer, R. L. & Skrydstrup, T. (2009). Bio-supported palladium nanoparticles as a catalyst for Suzuki-Miyaura and Mizoroki-Heck reactions. Green Chemistry, 11, 2041-2046. https://doi.org/10.1039/b918351p

Displaying results 2861 to 2870 out of 3469

287