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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

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Song, J., Xia, X., Chen, J., Xia, D., Xue, Q., Li, Q. & Dong, M. (2020). Folding 2D Graphene Nanoribbons into 3D Nanocages Induced by Platinum Nanoclusters. Journal of Physical Chemistry C, 124(19), 10495-10501. https://doi.org/10.1021/acs.jpcc.0c00463

Nielsen, K. H. (2020). Fordomsfulde algoritmer. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2020). Forskning, der kan undslippe. Weekendavisen, (Sektion 4 (Ideer)), 5.

Nielsen, K. H. (2020). Gode mutationer. Weekendavisen, (Sektion 4 (Ideer)), 5.

Kastorp, C. F. P., Duncan, D. A., Scheffler, M., Thrower, J. D., Jørgensen, A. L., Hussain, H., Lee, T. L., Hornekær, L. & Balog, R. (2020). Growth and electronic properties of bi- And trilayer graphene on Ir(111). Nanoscale, 12(38), 19776-19786. https://doi.org/10.1039/d0nr04788k

Zhang, C., Wang, Z., Tu, R., Dong, M., Li, J., Yang, M., Li, Q., Shi, J., Li, H., Ohmori, H., Zhang, S., Zhang, L. & Goto, T. (2020). Growth of self-aligned single-crystal vanadium carbide nanosheets with a controllable thickness on a unique staked metal substrate. Applied Surface Science, 499, Article 143998. https://doi.org/10.1016/j.apsusc.2019.143998

Simonsen, F. D. S., Jensen, P. A., Skov, A. W., Jaganathan, R., Thrower, J. & Hornekær, L. (2020). H2 catalysis through superhydrogenation of interstellar polycyclic aromatic hydrocarbons. In F. Salama & H. Linnartz (Eds.), Laboratory Astrophysics: From Observations to Interpretation (Vol. 15, pp. 264-266). Cambridge University Press. https://doi.org/10.1017/S1743921320000034

Ke, P. C., Zhou, R., Serpell, L. C., Riek, R., Knowles, T. P. J., Lashuel, H. A., Gazit, E., Hamley, I. W., Davis, T. P., Fändrich, M., Otzen, D. E., Chapman, M. R., Dobson, C. M., Eisenberg, D. S. & Mezzenga, R. (2020). Half a century of amyloids: past, present and future. Chemical Society Reviews, 49(15), 5473-5509. https://doi.org/10.1039/c9cs00199a

Fang, X., Wang, Z., Kang, S., Zhao, L., Jiang, Z. & Dong, M. (2020). Hexagonal CoSe₂ nanosheets stabilized by nitrogen-doped reduced graphene oxide for efficient hydrogen evolution reaction. International Journal of Hydrogen Energy, 45(3), 1738-1747. https://doi.org/10.1016/j.ijhydene.2019.11.059

Nielsen, K. H. (2020). Hvem tilhører Den Gamle? Weekendavisen, (Sektion 4 (Ideer)), 5.

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