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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Consiglieri, E., Xu, Q., Bregnhøj, M., Westberg, M., Ogilby, P. R. & Losi, A. (2019). Single mutation in a novel bacterial LOV protein yields a singlet oxygen generator. Photochemical & Photobiological Sciences, 18(11), 2657-2660. https://doi.org/10.1039/C9PP00328B

Ade, C. A., Brodszkij, E., Thingholm, B., Gal, N., Itel, F. R., Taipaleenmäki, E. M., Schattling, P. & Stadler, B. M. (2019). Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers. ACS Applied Polymer Materials, 1(6), 1532-1539. https://doi.org/10.1021/acsapm.9b00308

Verboom, K., Everaert, C., Bolduc, N., Livak, K. J., Yigit, N., Rombaut, D., Anckaert, J., Lee, S., Venø, M. T., Kjems, J., Speleman, F., Mestdagh, P. & Vandesompele, J. (2019). SMARTer single cell total RNA sequencing. Nucleic Acids Research, 47(16), Article e93. https://doi.org/10.1093/nar/gkz535

Hornekær, L. (2019). Stabilizing a C-H bond on graphene with sound. Science (New York, N.Y.), 364(6438), 331-332. https://doi.org/10.1126/science.aax1980

Kristoffersen, E. L. & Birkedal, V. (2019). Stable Off-Path Structures in the Folding Dynamics of Two Consecutive Telomeric DNG G-Quadruplexes. 138A-138A. https://doi.org/10.1016/j.bpj.2018.11.764

Cui, H., Gu, Z., Chen, X., Lin, L., Wang, Z., Dai, X., Yang, Z., Liu, L., Zhou, R. & Dong, M. (2019). Stimulating antibacterial activities of graphitic carbon nitride nanosheets with plasma treatment. Nanoscale, 11(39), 18416-18425. https://doi.org/10.1039/c9nr03797g

Prabha, R. D., Nair, B. P., Ditzel, N., Kjems, J., Nair, P. D. & Kassem, M. (2019). Strontium functionalized scaffold for bone tissue engineering. Materials Science and Engineering C, 94, 509-515. https://doi.org/10.1016/j.msec.2018.09.054

Timcenko, M., Lyons, J. A., Januliene, D., Ulstrup, J. J., Dieudonné, T., Montigny, C., Ash, M. R., Karlsen, J. L., Boesen, T., Kühlbrandt, W., Lenoir, G., Moeller, A. & Nissen, P. (2019). Structure and autoregulation of a P4-ATPase lipid flippase. Nature, 571(7765), 366-370. https://doi.org/10.1038/s41586-019-1344-7

Ye, J., Jin, L., Zhao, X., Qian, X. & Dong, M. (2019). Superior adsorption performance of metal-organic-frameworks derived magnetic cobalt-embedded carbon microrods for triphenylmethane dyes. Journal of Colloid and Interface Science, 536, 483-492. https://doi.org/10.1016/j.jcis.2018.10.073

Kang, S., He, M., Chen, M., Liu, Y., Wang, Y., Wang, Y., Dong, M., Chang, X. & Cui, L. (2019). Surface Amino Group Regulation and Structural Engineering of Graphitic Carbon Nitride with Enhanced Photocatalytic Activity by Ultrafast Ammonia Plasma Immersion Modification. ACS Applied Materials & Interfaces, 11(16), 14952-14959. https://doi.org/10.1021/acsami.9b01068

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Kalinka Hansen