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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, K. H. (2021). Wittgenstein, Popper og ildrageren. Weekendavisen, (Sektion 4 (Ideer)), 5.

Zhang, Z., Jørgensen, M. L., Wang, Z., Amagat, J., Wang, Y., Li, Q., Dong, MD. & Chen, M. (2020). 3D anisotropic photocatalytic architectures as bioactive nerve guidance conduits for peripheral neural regeneration. Biomaterials, 253, Article 120108. https://doi.org/10.1016/j.biomaterials.2020.120108

Zhang, Y., Zhang, Z., Wang, Y., Su, Y. & Chen, M. (2020). 3D myotube guidance on hierarchically organized anisotropic and conductive fibers for skeletal muscle tissue engineering. Materials Science and Engineering C, 116, Article 111070. https://doi.org/10.1016/j.msec.2020.111070

Basse-O'Connor, A., Podolskij, M. & Thäle, C. (2020). A Berry-Esseén theorem for partial sums of functionals of heavy-tailed moving averages. Electronic Journal of Probability, 25, 1-31. Article 31. https://doi.org/10.1214/20-EJP435

Su, Y., Taskin, M. B., Dong, MD., Han, X., Besenbacher, F. & Chen, M. (2020). A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration. Materials Chemistry Frontiers, 4(7), 2149-2156. https://doi.org/10.1039/D0QM00125B

Javed, I., Zhang, Z., Adamcik, J., Andrikopoulos, N., Li, Y., Otzen, D. E., Lin, S., Mezzenga, R., Davis, T. P., Ding, F. & Ke, P. C. (2020). Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC. Advanced Science, 7(18), Article 2001299. https://doi.org/10.1002/advs.202001299

Stoll, L., Rodríguez-Trejo, A., Guay, C., Brozzi, F., Bayazit, M. B., Gattesco, S., Menoud, V., Sobel, J., Marques, A. C., Venø, M. T., Esguerra, J. L. S., Barghouth, M., Suleiman, M., Marselli, L., Kjems, J., Eliasson, L., Renström, E., Bouzakri, K., Pinget, M. ... Regazzi, R. (2020). A circular RNA generated from an intron of the insulin gene controls insulin secretion. Nature Communications, 11, Article 5611. https://doi.org/10.1038/s41467-020-19381-w

Pedersen, J. N., Lyngsø, J., Zinn, T., Otzen, D. & Pedersen, J. S. (2020). A complete picture of protein unfolding and refolding in surfactants. Chemical Science, 11(3), 699-712. https://doi.org/10.1039/C9SC04831F

Das Mahapatra, K., Pasquali, L., Søndergaard, J. N., Lapins, J., Nemeth, I. B., Baltás, E., Kemény, L., Homey, B., Moldovan, L. I., Kjems, J., Kutter, C., Sonkoly, E., Kristensen, L. S. & Pivarcsi, A. (2020). A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma. Scientific Reports, 10, Article 3637. https://doi.org/10.1038/s41598-020-59660-6

Su, Y., Zhang, Z., Wan, Y., Zhang, Y., Wang, Z., Klausen, L. H., Huang, P., Dong, MD., Han, X., Cui, B. & Chen, M. (2020). A hierarchically ordered compacted coil scaffold for tissue regeneration. NPG Asia Materials, 12(1), Article 55. https://doi.org/10.1038/s41427-020-0234-7

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Kalinka Hansen