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Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Wang, X., Sun, F., Yin, G., Wang, Y., Liu, B. & Dong, M. (2018). Tactile-sensing based on flexible PVDF nanofibers via electrospinning: A review. Sensors (Switzerland), 18(2), Article 330. https://doi.org/10.3390/s18020330

Moein Moghimi, S. & Howard, K. (2018). Targeting Biological Barriers. Molecular Therapy, 26(4), 933-934. https://doi.org/10.1016/j.ymthe.2018.03.008

Nielsen, K. H. (2018). Teknologi. Weekendavisen, Sektion 4 (Ideer), 10.

Haydell, M. W., Centola, M., Adam, V., Valero Moreno, J. & Famulok, M. (2018). Temporal and Reversible Control of a DNAzyme by Orthogonal Photoswitching. Journal of the American Chemical Society, 140(49), 16868-16872. https://doi.org/10.1021/jacs.8b08738

Nielsen, K. H. (2018). Tesla. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2018). Thalidomid. Weekendavisen, Sektion 4 (Ideer), 10.

Wang, Z., Li, Q., Chen, Y., Cui, B., Li, Y., Besenbacher, F. & Dong, M. (2018). The ambipolar transport behavior of WSe₂ transistors and its analogue circuits. NPG Asia Materials, 10(8), 703-712. https://doi.org/10.1038/s41427-018-0062-1

Berdyugina, S. V., Kuhn, J. R., Langlois, M., Moretto, G., Krissansen-Totton, J., Catling, D., Grenfell, J. L., Santl-Temkiv, T., Finster, K., Tarter, J., Marchis, F. & Apai, D. (2018). The Exo-Life Finder (ELF) telescope: New strategies for direct detection of exoplanet biosignatures and technosignatures. In Ground-based and Airborne Telescopes VII (Vol. 10700). SPIE - International Society for Optical Engineering. https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10700/107004I/The-Exo-Life-Finder-ELF-telescope--New-strategies-for/10.1117/12.2313781.short?SSO=1

Bell, J. S., Hayes, S., Whitford, C., Sanchez-Weatherby, J., Shebanova, O., Vergari, C., Winlove, C. P., Terrill, N., Sorensen, T., Elsheikh, A. & Meek, K. M. (2018). The hierarchical response of human corneal collagen to load. Acta Biomaterialia, 65, 216-225. https://doi.org/10.1016/j.actbio.2017.11.015

Röcker, A. E., Müller, J. A., Dietzel, E., Harms, M., Krüger, F., Heid, C., Sowislok, A., Riber, C. F., Kupke, A., Lippold, S., von Einem, J., Beer, J., Knöll, B., Becker, S., Schmidt-Charnasit, J., Otto, M., Vapalahti, O., Zelikin, A. N., Bitan, G. ... Münch, J. (2018). The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Research, 152, 26-35. https://doi.org/10.1016/j.antiviral.2018.02.003

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