Find

AUNAB - Aarhus University Network on Artificial Biology

Publications

Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

Sort by: Date | Author | Title

He, J., Becares, E. R., Thulstrup, P. W., Gamon, L. F., Pedersen, J. N., Otzen, D., Gourdon, P., Davies, M. J. & Hägglund, P. (2020). Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin. Redox Biology, 36, Article 101631. https://doi.org/10.1016/j.redox.2020.101631

Nielsen, K. H. (2020). Pest eller petitesse. Weekendavisen, Sektion 4 (Ideer)(46), 5. Article e7fc83e9.

Baldry, M., Bojer, M. S., Najarzadeh, Z., Vestergaard, M., Meyer, R. L., Otzen, D. E. & Ingmer, H. (2020). Phenol-Soluble Modulins Modulate Persister Cell Formation in Staphylococcus aureus. Frontiers in Microbiology, 11, Article 573253. https://doi.org/10.3389/fmicb.2020.573253

Song, Y., Li, P., Zhang, Z., Wang, Y., Zhang, Z., Liu, L. & Dong, M. (2020). Photodegradation of porphyrin-bound hIAPP(1-37) fibrils. New Journal of Chemistry, 44(22), 9438-9443. https://doi.org/10.1039/c9nj06082k

Qian, X. & Städler, B. (2020). Polydiacetylene-Based Biosensors for the Detection of Viruses and Related Biomolecules. Advanced Functional Materials, 30(49), Article 2004605. https://doi.org/10.1002/adfm.202004605

Brodszkij, E., Westensee, I. N., Bertelsen, M., Gal, N., Boesen, T. & Städler, B. (2020). Polymer–Lipid Hybrid Vesicles and Their Interaction with HepG2 Cells. Small, 16(27), Article 1906493. https://doi.org/10.1002/smll.201906493

Liu, S., Jiang, A., Wang, Z., Lin, M., Xia, D., Li, Q. & Dong, M. (2020). Porous coordination polymer-derived ultrasmall CoP encapsulated in nitrogen-doped carbon for efficient hydrogen evolution in both acidic and basic media. International Journal of Hydrogen Energy, 45(3), 1729-1737. https://doi.org/10.1016/j.ijhydene.2019.11.063

Nagaraj, M., Ahmed, M., Lyngsø, J., Vad, B. S., Bøggild, A., Fillipsen, A., Pedersen, J. S., Otzen, D. E. & Akbey, Ü. (2020). Predicted Loop Regions Promote Aggregation: A Study of Amyloidogenic Domains in the Functional Amyloid FapC. Journal of Molecular Biology, 432(7), 2232-2252. https://doi.org/10.1016/j.jmb.2020.01.044

Wang, J., Xu, H., Huo, Y., Wang, Y. & Dong, M. (2020). Progress of electrospray and electrospinning in energy applications. Nanotechnology, 31(13), Article 132001. https://doi.org/10.1088/1361-6528/ab52bb

Hjorth-Jensen, S. J., Oksanen, E., Nissen, P. & Sørensen, T. L. M. (2020). Prospects for membrane protein crystals in NMX. In P. C. E. Moody (Ed.), Neutron Crystallography in Structural Biology (pp. 47-68). Elsevier. https://doi.org/10.1016/bs.mie.2019.11.019

Displaying results 1031 to 1040 out of 3467

104

Revised 03.03.2026

-

Kalinka Hansen