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Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

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Mortensen, H. G., Otzen, D. E. & Pedersen, J. S. (2021). Ubiquitin forms conventional decorated micelle structures with sodium dodecyl sulfate at saturation. Journal of Colloid and Interface Science, 596, 233-244. https://doi.org/10.1016/j.jcis.2021.03.110

Nielsen, K. H. (2021). Uenighed om enighed. Weekendavisen, (Sektion 4 (Ideer)), 5.

Nielsen, K. H. (2021). Videnskab, der deler. Weekendavisen, (Sektion 4 (Ideer)), 5.

Nielsen, K. H. & Andersen, C. (2021). Videnskabshistorie. In P. Danholt & C. Gad (Eds.), Videnskab, teknologi og samfund: En introduktion til STS (pp. 21-40). Hans Reitzels Forlag.

Couzinie, Y. & Hirsch, C. (2021). Weakly reinforced Polya urns on countable networks. Electronic Communications in Probability, 26, Article 35. https://doi.org/10.1214/21-ECP404

Nielsen, K. H. (2021). Wittgenstein, Popper og ildrageren. Weekendavisen, (Sektion 4 (Ideer)), 5.

Zhang, Z., Jørgensen, M. L., Wang, Z., Amagat, J., Wang, Y., Li, Q., Dong, MD. & Chen, M. (2020). 3D anisotropic photocatalytic architectures as bioactive nerve guidance conduits for peripheral neural regeneration. Biomaterials, 253, Article 120108. https://doi.org/10.1016/j.biomaterials.2020.120108

Zhang, Y., Zhang, Z., Wang, Y., Su, Y. & Chen, M. (2020). 3D myotube guidance on hierarchically organized anisotropic and conductive fibers for skeletal muscle tissue engineering. Materials Science and Engineering C, 116, Article 111070. https://doi.org/10.1016/j.msec.2020.111070

Basse-O'Connor, A., Podolskij, M. & Thäle, C. (2020). A Berry-Esseén theorem for partial sums of functionals of heavy-tailed moving averages. Electronic Journal of Probability, 25, 1-31. Article 31. https://doi.org/10.1214/20-EJP435

Su, Y., Taskin, M. B., Dong, MD., Han, X., Besenbacher, F. & Chen, M. (2020). A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration. Materials Chemistry Frontiers, 4(7), 2149-2156. https://doi.org/10.1039/D0QM00125B

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