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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, M., Dauksaite, V., Kjems, J. & Gothelf, K. V. (2005). DNA-Directed Coupling of Organic Modules by Multiple Parallel Reductive Aminations and Subsequent Cleavage of Selected DNA Sequences. Bioconjugate Chemistry, 16(4), 981-985.

Trapgaard, I. H., Boetius, A. & Finster, K. (2005). Desulfobacter psychrotolerans sp.nov., a new psychrotolerant sulfate-reducing hacterium and descriptions of its physiological response to temperature changes. Antoine van Leeuwenhoek, 881-110.

Kjems, J., Jakobsen, M. R. & Lützelberger, M. (2005). In vitro Selection Strategy to Identify Antisense Target Sites in RNA or hnRNP Complexes: Application on HIV-1.

Kölln, J., Bredehorst, R. & Spillner, E. (2005). Engineering of human complement component C3 for catalytic inhibition of complement. Immunology Letters, 98(1), 49-56. https://doi.org/10.1016/j.imlet.2004.10.010

Hornekær, L., Baurichter, A., Petrunin, V. V., Field, D. & Luntz, A. C. (2005). Experimental study of H₂ formation on ices. In D. S. Lis, G. A. Blake & E. Herbst (Eds.), Proceedings IAU Symposium No. 231 (pp. 337)

Nielsen, K. H. (2005). Forskere og aktuel forskningskommunikation: En webbaseret spørgeskemaundersøgelse. http://www.si.au.dk/aktuelforskningskommunikation

Rosgaard, L., Pedersen, S., Meyer, A. & Andersen, E. S. (2005). Fra halm til alkohol. Aktuel Naturvidenskab, (3).

Nielsen, K. H., Dahlgaard, J. & Kjaer, C. R. (2005). Fremtidens forskningskommunikation. Aktuel Naturvidenskab, (6), 28-29.

Liesack, W., Finster, K. & Garrity, G. M. (Ed.) (2005). Genus II. Desulfuromusa Liesack and Finster 1994, 756^vp. In Bergey's Manual of Systematic Bacteriology (vol. 2, part C ed., pp. 1010-1012)

Liesack, W., Finster, K. & Garrity, G. M. (Ed.) (2005). Genus XI. Desulfospira Finster, Liesack and Tindall 1997e, 1274^vp (Effective publication: Finster, Liesack and Tindall 1997c, 207). In Bergey's manual of Systematic Bacteriology (vol. 2, part C ed., pp. 984-987)

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