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Literature List


  1. Akkaoui S, Johansson A; Yagoubi M, Haubek D, El hamidi A, Rida S, Claesson R, Ennibi O. Chemical Composition, Antimicrobial activity, in Vitro Cytotoxicity and Leukotoxin Neutralization of Essential Oil from Origanum vulgareagainst Aggregatibacter actinomycetemcomitans. Pathogens 2020; 9: 192.
  2. Oscarsson J, DiRienzo J, Johansson A. Editorial Comments to the Special Issue: "Aggregaterbacter actinomycetemcomitans-Gram-Negative Bacterial Pathogen". Pathogens 2020; 9: 441.
  3. Gomez-Bañuelos E, Johansson L, Konig MF, Lundquist A, Paz M, Buhlin K, Johansson A, Rantapää-Dahlqvist S, Andrade F. Exposure to Aggregatibacter Actinomycetemcomitansbefore Symptom Onset and the Risk of Evolving to Rheumatoid Arthritis. J Clin Med 2020; 9: 1906.
  4. Esberg A, Johansson A, Claesson R, Johansson I. 43-Year Temporal Trends in Immune Response to Oral Bacteria in a Swedish Population. Pathogens 2020; 9: 544.
  5. Claesson R, Chiang HM, Lindholm M, Höglund Åberg C, Haubek D, Johansson A, Oscarsson J. Characterization of Aggregatibacter actinomycetemcomitansSerotype b Strains with Five Different, Including Two Novel, Leukotoxin Promoter Structures. Vaccines 2020; 8: 398.
  6. Jensen AB, Isidor F, Lund M, Væth M, Johansson A, Lauritsen NN, Haubek D. Prevalence of Aggregatibacter actinomycetemcomitans and Periodontal Findings among 14 to 15-Year Old Danish Adolescents: A Descriptive Cross-Sectional Study. Pathogens 2020; 9: 1054.
  7. Oscarsson J, Claesson R, Bao K, Brundin M, Belibasakis GN. Phylogenetic Analysis of Filifactor alocis Strains Isolated from Several Oral Infections Identified a Novel RTX Toxin, FtxA. Toxins 2020; 12:687.
  8. Lindholm M, Metsäniitty M, Granström E, Oscarsson J. Outer membrane vesicle-mediated serum protection inAggregatibacter actinomycetemcomitans. J Oral Microbiol 2020; 12:1747857.
  9. Tossavainen H, Salovaara S, Hellman M, Ihalin R, Permi P. Dispersion from Cα or NH: 4D experiments for backbone resonance assignment of intrinsically disordered proteins.J Biomol NMR 2020; doi: 10.1007/s10858-020-00299-w.


  1. Jensen AB, Haubek D, Claesson R, Johansson A, Nørskov-Lauritsen N. Comprehensive antimicrobial susceptibility testing of a large collection of clinical strains of Aggregatibacter actinomycetemcomitans does not identify resistance to amoxicillin. J Clin Periodontol 2019; 46: 846-854.
  2. Pietiäinen M, Liljestrand JM, Akhi R, Buhlin K, Johansson A, Paju S, Salminen A, Mäntylä P, Sinisalo J, Tjäderhane L, Hörkkö S, Pussinen PJ. Saliva and Serum Immune Responses in Apical Periodontitis. J Clin Med 2019; 8: e889.
  3. Johansson A, Claesson R, Höglund Åberg C, Haubek, D, Lindholm M, Jasim S, Oscarsson J. Genetic Profiling of Aggregatibacter actinomycetemcomitans Serotype B Isolated from Periodontitis Patients Living in Sweden. Pathogens 2019; 8: e153.
  4. Jensen AB; Lund M; Nørskov-Lauritsen N; Johansson A; Claesson R; Reinholdt J; Haubek D. Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans Serotype B Is Not Reflected in Dissimilar Expression and Production of Leukotoxin. Pathogens 2019; 8: e211.
  5. Oscarsson J, Johansson A. Comment from the Editor to the Special Issue: “Periodontitis: From Dysbiotic Microbial Immune Response to Systemic Inflammation”. J Clin Med 2019; 8: e1706.
  6. Belibasakis GN, Maula T, Bao K, Lindholm M, Bostanci N, Oscarsson J, Ihalin R, Johansson A. Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans. Pathogens 2019; 8: e222.
  7. Oscarsson J, Claesson R, Lindholm M, Höglund Åberg C, Johansson A. Tools of Aggregatibacter actinomycetemcomitans to Evade the Host Response. J Clin Med 2019; 8: e1079.
  8. Ahlstrand T, Kovesjoki L, Maula T, Oscarsson J, Ihalin R. Aggregatibacter actinomycetemcomitans LPS binds human interleukin-8. J Oral Microbiol 2019; 11: e1549931.
  9. Ennibi OK, Claesson R, Akkaoui S, Reddahi S, Kwamin F, Haubek D, Johansson A. High salivary levels of JP2 genotype of Aggregatibacter actinomycetemcomitans is associated with clinical attachment loss in Moroccan adolescents. Clin Exp Dent Res 2019; 5: 44-51.
  10. Nørskov-Lauritsen N, Claesson R, Jensen, AB, Åberg CH, Haubek D. Aggregatibacter actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature. Pathogens 2019; 8: e243.


  1. Lopes JP, Stylianou M, Backman E, Holmberg S, Jass J, Claesson R, Urban CF. Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence. mBio 2018; 9: e02120-18.
  2. Ennibi OK, Claesson R, Akkaoui S, Reddahi S, Kwamin F, Haubek D, Johansson A. High salivary levels of JP2 genotype of Aggregatibacter actinomycetemcomitans is associated with clinical attachment loss in Moroccan adolescents. Clin Exp Dent Res 2018
  3. Lindholm M, Aung KM, Wai SN, Oscarsson, J. Role of OmpA1 and OmpA2 in Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus serum resistance. J Oral Microbiol 2018; 11:1, DOI: 10.1080/20002297.2018.1536192.
  4. Bao K, Bostanci N, Thurnheer T, Grossmann J, Wolski WE, Thay B, Belibasakis GN, Oscarsson J. Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters protein dynamics of other species within a polymicrobial oral biofilm. NPJ Biofilms Microbiomes 2018; 4:12, doi: 10.1038/s41522-018-0055-4. eCollection 2018.
  5. Engström M, Eriksson K, Lee L; Hermansson M, Johansson A, Nicholas AP, Gerasimcik N, Lundberg K, Klareskog L, Catrina AI, Lindberg T. Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis. J Translat Med 2018; 6: e214.
  6. Ihalin R, Eneslätt K, Asikainen S. Peptidoglycan-associated lipoprotein of Aggregatibacter actinomycetemcomitans induces apoptosis and production of proinflammatory cytokines via TLR2 in murine macrophages RAW 264.7 in vitro. J Oral Microbiol 2018;10:1442079.
  7. Ahlstrand T, Torittu A, Elovaara H, Välimaa H, Pöllänen MT, Kasvandik S, Högbom M, Ihalin R. Interactions between the Aggregatibacter actinomycetemcomitans secretin HofQ and host cytokines indicate a link between natural competence and interleukin-8 uptake. Virulence 2018;9(1):1205-1223.
  8. Ihalin R, Zhong D, Karched M, Chen C, Asikainen S. Phosphorylcholine epitope is located in Aggregatibacter actinomycetemcomitans fimbrial protein Flp 1. Med Microbiol Immunol 2018 (in press)
  9. Engström M, Eriksson K, Lee L, Hermansson M, Johansson A, Nicholas AP, Gerasimcik N, Lundberg K, Klareskog L, Catrina AI, Lindberg T. Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis. J Translat Med 2018; 6: e214.
  10. Lützen L, Olesen B, Voldstedlund M, Christensen J J, Moser C, Knudsen J D, Fuursted K, Hartmeyer G N, Chen M, Søndergaard T S, Rosenvinge F S, Dzajic E, Schønheyder H C & Nørskov-Lauritsen N. Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study, mar. 2018 I : International Journal of Infectious Diseases. 68, s. 83-87 5 s.
  11. Murra M, Lützen L, Ciechanowski A B, Zbinden R, Lund M, Villesen P & Nørskov-Lauritsen N. Whole genome sequencing of species isolated from human clinical specimens and description of sp. Nov, 25 apr. 2018 I: Journal of Clinical Microbiology.


  1. Ihalin R. Miscellaneous IL-1β-Binding Proteins of Aggregatibacter actinomycetemcomitans. In: Henderson B, editor. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infection. 2017 Hoboken, NJ, USA: John Wiley & Sons, Inc. pp. 373-386.
  2. Ahlstrand T, Tuominen H, Beklen A, Torittu A, Oscarsson J, Sormunen R, Pöllänen MT, Permi P, Ihalin R. A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8. Virulence 2017;8(2):115-134.
  3. Johansson A, Claesson R, Höglund Åberg C, Haubek D, Oscarsson J. The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains. J Periodont Res 2017;1-10. doi:10.1111/jre.12462.
  4. Claesson R, Höglund-Åberg C, Haubek D, Johansson A. Age-related prevalence and characteristics of Aggregatibacter actinomycetemcitans in periodontitis patients living in Sweden. J Oral Microbiol 2017; 9(1). doi/org/10.1080/20002297.2017.1334504.
  5. Johansson A, Dahlén G. Bacterial Virulence Factors that Contribute to Periodontal Pathogenesis. In: Bostanci N, Belibasakis G. (eds) Pathogenesis of Periodontal Diseases. Springer, Cham 2018; 31-49,  DOI: https://doi.org/10.1007/978-3-319-53737-5_4.​
  6. Högbom M, Ihalin R. Functional and structural characteristics of bacterial proteins that bind host cytokines. Virulence. 2017;8(8):1592-1601.


  1. Jensen AB, Ennibi OK, Ismaili Z, Poulsen K, Haubek D. The JP2 genotype of aggregatibacter actinomycetemcomitans and marginal periodontitis in the mixed dentition. J Clin Periodontol. 2016 jan;43(1):19-25. doi: 10.1111/jcpe.12486. Epub 2016 Jan 23. PubMed PMID: 26659719
  2. Pettersson M, Kelk P, Belibasakis G, Bylund D, Molin Thorén M, Johansson A. Titanium ions form particles that activates and execute IL-1β release from LPS-primed macrophages. J Periodontal Res (Accepted December 18, 2015).
  3. Johansson A, Buhlin K, Sorsa T, Pussinen P. Systemic Aggregatibacter actinomycetemccomitans leukotoxin-neutralizing antibodies in periodontitis. J Periodontol 2106 (Epub ahead of print August 3).
  4. Hirschfeld J, Roberts HM , Chapple ILC , Parcˇ ina M , Jepsen S , Johansson A, Claesson R. Effects of Aggregatibacter actinomycetemcomitans leukotoxin on neutrophil migration and extracellular trap formation. J Oral Microbiol 2016, 8: e33070.



  1. Claesson R, Gudmundson J, Höglund Åberg C, Haubek D, Johansson A. Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin. J Oral Microbiol 2015; 7: 26974e.
  2. Buhlin K, Holmer J, Gustafsson A, Hörkkö S, Pockley AG, Johansson A, Paju S, Klinge B, Pussinen PJ. Association of periodontitis with persistent, pro-atherogenic antibody responses.J Clin Periodontol 2015; 42: 1006–1014.
  3. Höglund Åberg C, Kelk P, Johansson A. Aggregatibacter actinomycetemcomitans: virulence of its leukotoxin and association with aggressive periodontitis. Virulence 2015; 6: 188-195.
  4. Rompikuntal P.K, Vdovikova S, Duperthuy M, Johnson T.L, Åhlund M, Lundmark R, Oscarsson J, Sandkvist M, Uhlin B.E, Wai S.N. Outer Membrane Vesicle-Mediated Export of Processed PrtV Protease from Vibrio cholerae. PLoS One 10(7): e0134098. doi: 10.1371/journal.pone.0134098.
  5. Kieselbach T, Zijnge V, Granström E, Oscarsson J. Proteomics of Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles. PLoS One 10(9): e0138591. doi: 10.1371/journal.pone.0138591.
  6. Bao K, Bostanci N, Selevsek N, Thurnheer T, Belibasakis GN. Quantitative proteomics reveal distinct protein regulations caused by Aggregatibacter actinomycetemcomitans within subgingival biofilms. PLoS One 2015; 10: 3: e0119222
  7. Thurnheer T. Belibasakis GN. Integration of non-oral bacteria into in vitro oral biofilms. Virulence 2015; 6: 3: 258-264



  1. Höglund Åberg C, Kwamin F, Claesson R, Dahlén G, Johansson A, Haubek D. Progression of attachment loss is strongly associated with presence of the JP2 genotype of Aggregatibacter actinomycetemcomitans: a prospective cohort study of a young adolescent population. J Clin Periodontol 2014; 41: 232-241
  2. Gonzales JR, Groeger S, Johansson A, Meyle J. T helper cells from aggressive periodontitis patients produce higher levels of interleukin-1 beta and interleukin-6 in interaction with Porphyromonas gingivalis. Clin Oral Investig 2014 18: 1835-1843.
  3. Dahlén G, Claesson G, Höglund Åberg C, Haubek D, Johansson A, Kwamin F. Subgingival bacteria in Ghanaian adolescents with or without progression of attachment loss. J Oral Microbiol 2014; 6: e23977.
  4. Höglund Åberg C, Haubek D, Kwamin F, Johansson A, Claesson R. Leukotoxic Activity of Aggregatibacter actinomycetemcomitans and Periodontal Attachment Loss. PLoS One 2014; 9: e104095.
  5. Haubek D, Johansson A. Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis. J Oral Microbiol 2014; 6: e23980.
  6. Thay, B., Damm, A., Kufer, T., Wai, S.N., and Oscarsson, J. Aggregatibacter actinomycetemcomitans outer membrane vesicles are internalized in human host cells and trigger NOD1- and NOD2-dependent NF-kB activation. Infection and Immunity 82:4034-4046.
  7. Enow, C., Oscarsson, J., Zlatkov, N., Westermark, M., Duperthuy, M., Wai, S.N., Uhlin, B.E. Elevated recombinant clyA gene expression in the uropathogenic Escherichia coli strain 536, a clue to explain pathoadaptive mutations in a subset of extraintestinal E. coli strains. BMC Microbiology 14(1):216.
  8. Nissen L, Sgorbati B, Biavati B, Belibasakis GN. Lactobacillus salivarius and L. gasseri down-regulate Aggregatibacter actinomycetemcomitans exotoxins expression. Ann Microbiol 2014; 64: 611-617.


  1. Höglund Åberg C, Antonoglou G, Haubek D, Kwamin F, Claesson R, Johansson A. Cytolethal distending toxin in isolates of Aggregatibacter actinomycetemcomitans from Ghanaian adolescents and association with serotype and disease progression.PLoS One 2013; 8: e65781.
  2. Thay, B., Wai, S.N., and Oscarsson, J. Staphylococcus aureus α-toxin-dependent induction of host cell death by membrane-derived vesicles. PLoS One 8(1):e54661. doi:10.1371/journal.pone.0054661.
  3. Paino A, Ahlstrand T, Nuutila J, Navickaite I, Lahti M, Tuominen H, Välimaa H, Lamminmäki U, Pöllänen MT, Ihalin R. Identification of a novel bacterial outer membrane interleukin-1Β-binding protein from Aggregatibacter actinomycetemcomitans. PLoS ONE 2013; 8(7): e70509.
  4. Pöllänen MT, Paino A, Ihalin R. Environmental stimuli shape biofilm formation and the virulence of periodontal pathogens. Int J Mol Sci 2013; 14(8):17221-17237.


  1. Höglund Åberg C, Kwamin F, Claesson R, Johansson A, Haubek D. Presence of JP2 and Non-JP2 Genotypes of Aggregatibacter actinomycetemcomitans and Periodontal Attachment Loss in Adolescents in Ghana. J Periodontol 2012; 83: 1520-1528.
  2. Ennibi OK, Benrachadi L, Bouziane A, Haubek D, Poulsen K. The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans in localized and generalized forms of aggressive periodontitis. Acta Odontol Scand. 2012 Jul;70(4):318-22. doi: 10.3109/00016357.2011.642002. Epub 2012 Jan 18. PubMed PMID: 22251014.
  3. Belibasakis G, Johansson A. Aggregatigacter actinomycetemcomitans targets NLRP3 and NLRP6 inflammasome expression in human mononuclear leukocytes. Cytokine 2012; 59:124-130.
  4. Kwamin F, Gref R, Haubek D, Johansson A. Interactions of extracts from selected chewing stick sources with Aggregatibacter actinomycetemcomitans. BMC Research Notes 2012; 5: e2023.
  5. Johansson A, Kalfas S. Virulence mechanisms of leukotoxin from Aggregatibacter actinomycetemcomitans. Oral Health / Book 2; In: Intech 2012; 12: 1-29, DOI: 10.5772/28191.
  6. Rompikuntal, P.K., Thay, B., Khan, M.K., Alanko, J., Penttinen, A-M., Asikainen, S.,Wai, S.N., and Oscarsson, J. Perinuclear localization of internalized outer membrane vesicles carrying active cytolethal distending toxin from Aggregatibacter actinomycetemcomitans. Infection and Immunity 80:31-42.
  7. Zijnge, V., Kieselbach, T., and Oscarsson, J. (2012). Proteomics of protein secretion by Aggregatibacter actinomycetemcomitans. PLoS One 7(7): e41662.
  8. doi:10.1371/journal.pone.0041662.
  9. Paino A, Lohermaa E, Korhonen J, Sormunen R, Tuominen H, Pöllänen MT, Ihalin R. Interleukin-1β is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and binds to the outer edges of nucleoids. Cytokine 2012; 60: 565-574.

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