AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

AUNAB is hosting an iGEM team to represent Aarhus University

- Research news

AUNAB has gathered a strong interdisciplinary team of 11 students across different educations, who will represent Aarhus University at the world's biggest synthetic biology competition, iGEM 2026. Read more about their process here.

Actin-Powered Motors Build Cytoskeletons in Artificial Cells

- Research news

AUNAB members Assistant Prof. Miguel Ramos Docampo's and Prof. Brigitte Stadler's effort to engineered artificial cells to form cytoskeleton-like networks using nanomotor-driven actin polymerization is published in ACS Nano. These hybrid vesicles merge active matter with synthetic biology to achieve life-like movement and self-organization inspired by Listeria’s actin-based propulsion.

 

Single Protein-Mediated Vesicle Division

- Research news

Steering group member of AUNAB, Prof. Brigitte Städler, has published a collaborative study in Advanced Materials on the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles.

Technology Roadmap of Micro/Nanorobots

- Research news

Aunab steering group member, Prof. Brigitte Städler, is among 103 authors who contributed to this Mega Review published in ACS Nano on the topic of Micro/Nanorobots, a field that celebrated its 20th anniversary last year.

Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes

- Research news

The design of artificial cells is a focal point of intense research efforts. One characteristic that remains particularly hard to engineer is the responsive behavior in artificial cells. It requires the design of molecular mechanisms to receive, interpret, and react to external environmental or biochemical stimuli. This challenge is specifically addressed herein and the design of artificial cells that respond to the external chemical messenger by the activation of intracellular catalysis is…

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Recent publications by network

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Bak, E. N., Bregnhøj, M., Nørnberg, P., Jensen, S. K., Thøgersen, J. & Finster, K. (2022). Spore Survival During Abrasive Saltation on Mars: A Reply to the Comment by Minns et al. Astrobiology, 22(9), 1032-1033. https://doi.org/10.1089/ast.2022.0085
Sahin, C., Østerlund, E. C., Österlund, N., Costeira-Paulo, J., Pedersen, J. N., Christiansen, G., Nielsen, J., Grønnemose, A. L., Amstrup, S. K., Tiwari, M. K., Rao, R. S. P., Bjerrum, M. J., Ilag, L. L., Davies, M. J., Marklund, E. G., Pedersen, J. S., Landreh, M., Møller, I. M., Jørgensen, T. J. D. & Otzen, D. E. (2022). Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization. Journal of the American Chemical Society, 144(27), 11949-11954. https://doi.org/10.1021/jacs.2c03607
Bisiak, F., Chrenková, A., Zhang, S. D., Pedersen, J. N., Otzen, D. E., Zhang, Y. E. & Brodersen, D. E. (2022). Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response. Journal of Biological Chemistry, 298(7), Article 102142. https://doi.org/10.1016/j.jbc.2022.102142
Hartmann, S., Ling, M., Dreyer, L. S. A., Zipori, A., Finster, K., Grawe, S., Jensen, L. Z., Borck, S., Reicher, N., Niedermeier, D., Jones, N. C., Hoffmann, S. V., Wex, H., Rudich, Y., Boesen, T. & Santl-Temkiv, T. (2022). Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity. Frontiers in Microbiology, 13, Article 872306. https://doi.org/10.3389/fmicb.2022.872306
Nguyen, M. T. A., Pothoulakis, G. & Andersen, E. S. (2022). Synthetic Translational Regulation by Protein-Binding RNA Origami Scaffolds. ACS Synthetic Biology, 11(5), 1710-1718. https://doi.org/10.1021/acssynbio.1c00608
Symons, R. A., Colella, F., Collins, F. L., Rafipay, A. J., Kania, K., McClure, J. J., White, N., Cunningham, I., Ashraf, S., Hay, E., Mackenzie, K. S., Howard, K. A., Riemen, A. H. K., Manzo, A., Clark, S. M., Roelofs, A. J. & De Bari, C. (2022). Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis. Annals of the Rheumatic Diseases, 81(2), 214-224. https://doi.org/10.1136/annrheumdis-2021-220875
Rasmussen, H. Ø., Wollenberg, D. T. W., Wang, H., Andersen, K. K., Oliveira, C. L. P., Jørgensen, C. I., Jørgensen, T. J. D., Otzen, D. E. & Pedersen, J. S. (2022). The changing face of SDS denaturation: Complexes of Thermomyces lanuginosus lipase with SDS at pH 4.0, 6.0 and 8.0. Journal of Colloid and Interface Science, 614, 214-232. https://doi.org/10.1016/j.jcis.2021.12.188
Svenningsen, E. B., Ottosen, R. N., Jørgensen, K. H., Nisavic, M., Larsen, C. K., Hansen, B. K., Wang, Y., Lindorff-Larsen, K., Tørring, T., M. Hacker, S. & Poulsen, T. (2022). The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21. Poster session presented at EMBO Chemical Biology, Heidelberg, Germany.
Svenningsen, E. B., Ottosen, R. N., Jørgensen, K. H., Nisavic, M., Larsen, C. K., Hansen, B. K., Wang, Y., Lindorff-Larsen, K., Tørring, T., Hacker, S. M., Palmfeldt, J. & Poulsen, T. B. (2022). The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21. RSC Chemical Biology, 3(10), 1216-1229. https://doi.org/10.1039/d2cb00161f
Farzadfard, A., Pedersen, J. N., Meisl, G., Somavarapu, A. K., Alam, P., Goksøyr, L., Nielsen, M. A., Sander, A. F., Knowles, T. P. J., Pedersen, J. S. & Otzen, D. E. (2022). The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization. Communications Biology, 5(1), 123. Article 123. https://doi.org/10.1038/s42003-022-03059-8

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Revised 03.03.2026
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Kalinka Hansen