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Recent research news on Artificial Biology

Single Protein-Mediated Vesicle Division

Steering group member of AUNAB, Prof. Brigitte Städler, has published a collaborative study in Advanced Materials on the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles.

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Xi, X., Zhang, Y., Zhao, D., Chen, F. & Howard, K. A. (2026). A modular “Catch-and-Play” platform for rapid T-cell engager target assembly for personalised cancer treatment. Signal Transduction and Targeted Therapy, 11(1), Article 18. https://doi.org/10.1038/s41392-025-02557-5
Hopkinson, A. T., Wilson, A. M., Pitfield, J., Muiña, A. T., Rácz, R., Mifsud, D. V., Herczku, P., Lakatos, G., Sulik, B., Juhász, Z., Biri, S., McCullough, R. W., Mason, N. J., Scavenius, C., Hornekær, L. & Ioppolo, S. (2026). An interstellar energetic and non-aqueous pathway to peptide formation. Nature Astronomy. Advance online publication. https://doi.org/10.1038/s41550-025-02765-7
Samanta, A., Malle, M. G., Tsang, E., Omer, M., Skaanning, M. K., Youssef, S., Kjems, J. & Gothelf, K. V. (2026). Bacteriophage-Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery. Advanced Science, 13(10), Article e12844. https://doi.org/10.1002/advs.202512844
Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E. & Morshedi, D. (2026). Corrigendum to “The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier” [Int. J. Biol. Macromol. Volume 290 (2025), 140387] (S0141813025009365), (10.1016/j.ijbiomac.2025.140387). International Journal of Biological Macromolecules, 337, Article 149909. https://doi.org/10.1016/j.ijbiomac.2025.149909
Khider, M. L. K., Irla, M., López, M. G., Gispert, A., Konjetzko, T., Meliawati, M., Schmid, J., Brautaset, T. & Brito, L. F. (2026). CRISPR-Cas9-driven genome editing in Bacillus methanolicus MGA3. Frontiers in Microbiology, 16, Article 1728984. https://doi.org/10.3389/fmicb.2025.1728984
Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158
Irla, M., Brito, L. F., Langlo, J., Wohlers, C., Benninghaus, L., Heid, C., Wendisch, V. F., Schmid, J. & Brautaset, T. (2026). Development of a markerless tool for targeted chromosome modification in the thermophilic and methylotrophic bacterium Bacillus methanolicus. Microbial Cell Factories, 25(1), Article 10. https://doi.org/10.1186/s12934-025-02880-0
López Hernández, M., Scavenius, C., Otzen, D. E. & Pedersen, J. S. (2026). Divergent effects of anionic surfactants on laundry enzymes: Structural stability, activity modulation, and self-cleavage mechanisms. International Journal of Biological Macromolecules, 335(1), Article 149069. https://doi.org/10.1016/j.ijbiomac.2025.149069
Wang, J., Yang, K., Klausen, L. H., Song, C., Ma, Z., Zhang, H., Liu, L. & Dong, M. (2026). Exploring Photoacoustic Vibration of Quartz for Constructing a Versatile Photoacoustic Sensor. Analytical Chemistry, 98(6), 4609-4617. https://doi.org/10.1021/acs.analchem.5c05747
Holleufer, S. F., Hvidt, U. G., Kolasseri, I. A., Chen, Y. P., Li, Z., Lauritsen, J. V., Hornekær, L. & Cassidy, A. (2026). Formation and oxygen intercalation of vitreous 2D silica bilayer films on Ir(111). Physical Chemistry Chemical Physics. Advance online publication. https://doi.org/10.1039/d5cp04298d

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Revised 03.03.2026
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Kalinka Hansen