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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Alam, P., Bousset, L., Melki, R. & Otzen, D. E. (2019). α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities. Journal of Neurochemistry, 150(5), 522-534. https://doi.org/10.1111/jnc.14808

Nielsen, K. H. (2018). #. Weekendavisen, Sektion 4 (Ideer), 10.

Valero Moreno, J., Pal, N., Dhakal, S., Walter, N. G. & Famulok, M. (2018). A bio-hybrid DNA rotor–stator nanoengine that moves along predefined tracks. Nature Nanotechnology, 13(6), 496-503. https://doi.org/10.1038/s41565-018-0109-z

Mateos-Rivera, A., Øvreås, L., Wilson, B., Yde, J. C. & Finster, K. W. (2018). Activity and diversity of methane-oxidizing bacteria along a Norwegian sub-Arctic glacier forefield. FEMS Microbiology Ecology, 94(5), 1-11. Article fiy059. https://doi.org/10.1093/femsec/fiy059

Zheng, N., He, J., Gao, J., Huang, Y., Besenbacher, F. & Dong, M. (2018). Adhesion force measured by atomic force microscopy for direct carbon fiber-epoxy interfacial characterization. Materials and Design, 145, 218-225. https://doi.org/10.1016/j.matdes.2018.02.060

Santl-Temkiv, T., Gosewinkel, U., Starnawski, P., Lever, M. & Finster, K. (2018). Aeolian dispersal of bacteria in southwest Greenland: their sources, abundance, diversity and physiological states. FEMS Microbiology Ecology, 94(4), Article fiy031. https://doi.org/10.1093/femsec/fiy031

Fazekas-Singer, J., Singer, J., Ilieva, K. M., Matz, M., Herrmann, I., Spillner, E., Karagiannis, S. N. & Jensen-Jarolim, E. (2018). AllergoOncology: Generating a canine anti-cancer IgE against the epidermal growth factor receptor. Journal of Allergy and Clinical Immunology, 142(3), 973-976.e11. https://doi.org/10.1016/j.jaci.2018.04.021

Knudsen, C. H., ásgrímsdóttir, E. S., Rahimi, K., Gill, K. P., Frandsen, S., Buchholdt, S. H., Chen, M., Kjems, J., Febbraro, F. & Denham, M. (2018). A modified monomeric red fluorescent protein reporter for assessing CRISPR activity. Frontiers in Cell and Developmental Biology, 6(MAY), Article 54. https://doi.org/10.3389/fcell.2018.00054

Huo, P., Zhao, P., Wang, Y., Liu, B. & Dong, MD. (2018). An effective utilization of solar energy: Enhanced photodegradation efficiency of TiO₂/graphene-based composite. Energies, 11(3), 630-649. Article 630. https://doi.org/10.3390/en11030630

Jiang, H., Wang, Z., Yang, Q., Hanif, M., Wang, Z., Dong, L. & Dong, M. (2018). A novel MnO₂/Ti₃C₂Tx MXene nanocomposite as high performance electrode materials for flexible supercapacitors. Electrochimica Acta, 290, 695-703. https://doi.org/10.1016/j.electacta.2018.08.096

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Kalinka Hansen