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What is target validation?

The purpose of target validation is to show how a given target is involved in disease and how it can be manipulated using drugs to  give a therapeutic effect.

Why does ODIN focus on target validation?

One of the critical points in the drug development process, is the transition from animal model systems to human testing. At this point, researchers find that many drugs fail therapeutically or have off-target effects. A more thorough validation can help researchers discard drug candidates at an earlier step and thereby make the process more efficient and much less expensive.

ODIN aims to develop multiple screening methods for target validation. This can be achieved by ODIN through the inherent close collaboration with industry, thus creating synergies to speed up and enhance precision in drug development.

The different screening methods for target validation will greatly improve testing of drug precision while also speeding up drug development. This will give important insights into targets and improved understanding of diseases of interest, which in turn will lower the barrier to drug development.