MBG Focus Talk by Dr. Verne Lee


"Megasynthase enzymes that assemble diverse molecules: Structural studies of nonribosomal peptide synthetases and their products"

Nonribosomal peptide synthetases (NRPSs) are large, multidomain “megasynthase” enzymes that are involved in the biosynthesis of an array of secondary metabolites. The short peptide products of NRPSs play diverse biological roles including signalling, nutrient acquisition and defence while also being a major source of potentially valuable natural products. This talk will introduce NRPSs and their products with a focus on the structural investigation into an NRPS enzyme from an endophytic fungi and its product, a novel iron-binding siderophore. This siderophore has been found to play a critical role in maintaining the mutualistic character of the relationship between the fungus and its host plant, perennial ryegrass, a major forage grass species in Australasia. The talk will also touch on the recent discovery of NRPSs in rumen methanogens, the first megasynthases to be identified in Archaea, and the opportunities that this discovery may provide in the field of mitigating greenhouse gas emissions from livestock.


Tuesday 28 May 2013 at 3:15 pm
Department of Physics Main Auditorium, 1523-318