NANORIPES

  • Centre for Natural Non-Ribosomal Peptide Synthesis

This project has been completed. For further information please contact Ditlev E. Brodersen

Welcome to NANORIPES

The Centre for Natural Non-Ribosomal Peptide Synthesis (NANORIPES) studies the molecular and genetic background for synthesis of bioactive peptides in fungi. By using giant enzymes known as Non-Ribosomal Peptide Synthetases (NRPSs) instead of ribosomes to produce peptides, and by encoding the sequence information within these enzymes rather than relying on mRNA, fungi are able to produce peptides with a very wide chemical variety and high level of bioactivity. Several well-known antibiotics, such as penicillin and the immunosuppressant, cyclosporine, are NRPS products.

Project Opportunities

The The NANORIPES center is seeking enthusiastic and diligent undergraduate and graduate students for projects in the DEB–lab.

The non-ribosomal peptide synthetases (NRPSs) constitute a large group of biosynthetic enzymes found in both bacteria and fungi responsible for producing a wide range of bioactive polypeptides. Well-known examples of products synthesized by NRPSs are the antibiotic penicillin and the immunosuppressant cyclosporin... [read more]

NANORIPES 2st scientific Meeting

Thank you all for a good meeting with great scientific input. A special thank should go to Verne for coming all the way to Denmark and for a very inspiring talk.

NANORIPES 2st scientific Meeting
Back: Rasmus Kock Flygaard, Christian Storm Petersen, Klaus Westphall, Jens Laurids Sørensen, Michael Knudsen, Claus Olesen, Frederik Teilfeldt Hansen, Kasper, Patricia Romans Fuertes Front: Kinga Kosim, Henriette Giese, Teis Esben Søndergaard, Ditlev Egeskov Brodersen, Verne Lee, Wagma Saei

News & Events

15-16. September 2014 Nanoripes 4th Scientific Meeting.

The 4th Scientific Meeting in Nanoripes, will be held in the beautiful surroundings at Klitgaarden refugium in Skagen

We are looking forward to hear more about the advancements in the labs of our collaborators.

Lokation: Klitgaarden, Skagen

 --------------------------------------------

13. March, Erasmus student Emeline Ricciuti ends stay.

Emeline has worked with great enthusiasm, dedication and diligence in our lab. She has achieved great results for the benefit of the whole NANORIPES centre. Her work will be concluded in a written assignment.

--------------------------------------------

20. January, Erasmus student Emeline Ricciuti is joning Nanoripes

We are pleased to welcome Emeline Ricciuti at the Nanoripes center. Emeline is joining the team in late January 2014 and her work will focus on the expression of soluble NRPS domains.

 --------------------------------------------

16. January 2014 09:30 - 16:00

Thank you all for some very inspirational talks and a good time.

NANORIPES 3st Scientific Meeting

Stinesminde, Hobro

 --------------------------------------------

1th of December, Bachelor Student Janus Adler is joining the team. 

Janus’ work is aiming towards expression of NRPS’ in Pichia Pastoris. His work will build on the foundation already made by previous studies performed in the DEB laboratory. We are all looking forward to see the results of Janus’ work in the near future.

 --------------------------------------------

3th of July, Master Student Rasmus Kock Flygaard ends stay 

Rasmus Kock FlygaardRasmus Kock Flygaard has been enrolled at GSST Ph.D school. His project will be carried out in the LBJ-laboratory under the supervision of associate professor Lasse Bohl Jenner. Rasmus has shown great enthusiasm, and been tremendous diligent in his work at the NANORIPES centre. He has particularly distinguished himself by being very independent, creative and solution-oriented; this has lead to big results in the laboratory. Rasmus’ candid mood has also contributed to the excellent work environment of DEB-lab. We wish you all the best in your new position and hope to see you around.

--------------------------------------------

19th of June, Erasmus Student Kinga Kosim Completes Stay

Master student Kinga Kosim from University of Warsaw, (Poland) have been working in the DEB-lab for the past 4 months. Kingas work has mainly focused on protein expression and purification of constructs from NRPS adenylation domains. She has achieved solid results that have contributed to the future progress in the NANORIPES centre. Her work has ended in a report.

--------------------------------------------

18th of June, Bachelor Project is Coming to an End

Klaus Westphal is wrapping up his Bachelor project in these days. Klaus has been working with great enthusiasm and interest in the DEB-lab for the last 7 weeks. Through hard work he managed to achieve great results that really have contributed to the recent development in the NANORIPES centre.

--------------------------------------------

28th of May, MBG Focus Talk by Dr. Verne Lee

School of Medical Sciences, University of Auckland, New Zealand

"Megasynthase enzymes that assemble diverse molecules: Structural studies of nonribosomal peptide synthetases and their products"

Click for abstract

28th of May 2013 at 3:15 pm

--------------------------------------------

15 May 2013 09:30 - 18:00

NANORIPES 2st scientific Meeting

Aarhus, Science Park

--------------------------------------------

Visiting researcher 13th May - 6th June

Verne Lee, University of Auckland, NZ

Verne has been working with NRPS' for several years and
solved the first, and only structure of an eukaryotic NRPS adenylation domain


"Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis"

--------------------------------------------

16 November 2012 10:00 - 16:00

NANORIPES 1st Scientific Meeting

Stinesminde, Hobro